Journal
DRUG DISCOVERY TODAY
Volume 11, Issue 17-18, Pages 812-818Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2006.07.005
Keywords
-
Categories
Ask authors/readers for more resources
Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is a key mechanism for solid tumor targeting, and considered a gold standard for novel drug design. In this review, we discuss various endogenous factors that can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment the EPR effect by use of exogenous agents, as well as practical methods available in the clinical setting. Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available