Journal
EXPERIMENTAL GERONTOLOGY
Volume 41, Issue 9, Pages 807-812Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.07.002
Keywords
aging; protein; post-translational modifications; oxidation; nitrotyrosine; farnesylation; transglutaminase; 2-oxo-histidine
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Funding
- NIA NIH HHS [AG25350, AG23551] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG023551, R01AG025350] Funding Source: NIH RePORTER
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Post-translational modifications of proteins are an important biologic tool for the production of various protein species from a single gene, which may vary in conformation, function, biologic half-life and complex formation with other proteins. The present minireview summarizes a few selected research observations important for the role of post-translational modifications in biologic aging and age-related diseases, including farnesylation, methylglyoxal-derivatization, transglutaminase pathways and the formation of 3-nitrotyrosine and 2-oxo-histidine in vivo. (c) 2006 Elsevier Inc. All rights reserved.
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