Journal
DEVELOPMENTAL CELL
Volume 11, Issue 3, Pages 289-300Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2006.08.006
Keywords
-
Categories
Funding
- NCI NIH HHS [P01 CA41086] Funding Source: Medline
- NIGMS NIH HHS [R01 GM076690] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA041086] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076690] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Pattern formation in developing organisms can be regulated at a variety of levels, from gene sequence to anatomy. At this level of complexity, mechanistic models of development become essential for integrating data, guiding future experiments, and predicting the effects of genetic and physical perturbations. However, the formulation and analysis of quantitative models of development are limited by high levels of uncertainty in experimental measurements, a large number of both known and unknown system components, and the multiscale nature of development. At the same time, an expanding arsenal of experimental tools can constrain models and directly test their predictions, making the modeling efforts not only necessary, but feasible. Using a number of problems in fruit fly development, we discuss how models can be used to test the feasibility of proposed patterning mechanisms and characterize their systems-level properties.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available