Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 61, Issue 6, Pages 575-584Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/61.6.575
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Funding
- Intramural NIH HHS [Z99 AG999999] Funding Source: Medline
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The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article IL-6: A Cytokine for Gerontologists, indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials.
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