Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 29, Issue 1, Pages 59-63Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02977469
Keywords
marine lichen-derived; Gliocladium sp.; secalonic acid D; cytotoxicity; cell cycle inhibition
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Secalonic acid D (SAD) was isolated as the major secondary metabolite of the marine lichen-derived fungus Gliocladium sp. T31. Its structure was established on the basic of physicochemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.
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