Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 22, Issue 1, Pages 52-56Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2006.22.52
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI044595] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01-AI44595] Funding Source: Medline
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Human endogenous retrovirus K (HERV-K) is distinctive among the retroviruses that comprise about 8% of the human genome in that multiple HERV-K proviruses encode full-length viral proteins, and many HERV-K proviruses formed during recent human evolution. HERV-K gag proteins are found in the cytoplasm of primary tumor cells of patients with seminoma. We identified HERV-K-specific T cells in patients with a past history of seminoma using the interferon-gamma ELISPOT assay and an MHC-HERV- K peptide-specific tetramer. A minority of apparently healthy subjects without evident germ cell tumors also made HERV-K-specific T cell responses. In summary, we detected T cell reactivity to HERV-K-peptides in both past seminoma patients and a minority of apparently healthy controls.
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