Journal
LUPUS
Volume 15, Issue 7, Pages 428-430Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/0961203306lu2328oa
Keywords
autoantibodies; autoimmunity bioinformatics; immunological homunculus; microarray
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Traditionally, immunologic diagnosis has been based on an attempt to correlate each disease with a specific immune reactivity, such as an antibody or a T-cell response to a single antigen specific for the disease entity. The state of the body, however, appears to be encoded by the immune system in collectives of reactivities and not by single reactivities. Here we describe our use of microarray technology and informatics to develop an antigen chip capable of detecting global patterns of antibodies binding to hundreds of antigens simultaneously. The patterns fashion diagnostic signatures.
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