Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 34, Issue 1, Pages 3-14Publisher
SPRINGER
DOI: 10.1007/s10439-005-9000-9
Keywords
nanoparticles; nanotechnology; fluorescence; living cells; living animals; molecular imaging; cytotoxicity; cationic peptides; bioconjugation; dynamic light scattering
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA108468] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060562, P20GM072069, R01GM058173] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA108468] Funding Source: Medline
- NIGMS NIH HHS [R01 GM060562, P20 GM072069, R01 GM058173] Funding Source: Medline
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Semiconductor quantum dots are luminescent nanoparticles that are under intensive development for use as a new class of optical imaging contrast agents. Their novel properties such as optical tunability, improved photostability, and multicolor light emission have opened new opportunities for imaging living cells and in vivo animal models at unprecedented sensitivity and spatial resolution. Combined with biomolecular engineering strategies for tailoring the particle surfaces at the molecular level, bioconjugated quantum dot probes are well suited for imaging single-molecule dynamics in living cells, for monitoring protein-protein interactions within specific intracellular locations, and for detecting diseased sites and organs in deep tissue. In this article, we describe the engineering principles for preparing high-quality quantum dots and for conjugating the dots to biomolecular ligands. We also discuss recent advances in using quantum dots for in vivo molecular and cellular imaging.
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