Journal
NATURE CHEMICAL BIOLOGY
Volume 2, Issue 1, Pages 29-30Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio753
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Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.
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