Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 54, Issue 1, Pages 73-77Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2005.08.014
Keywords
Etest; synergy heterogeneous resistant S. aureus; daptomycin; linezolid; quinupristin/dalfopristin; rifampin; vancomycin ampicillin/sulbactam; gentamicin
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In search for potential synergistic antimicrobial combinations against Staphylococcus aureus isolates, which display heterogeneous resistance to vancomycin, we evaluated the activities of 21 various combinations involving ampicillin/sulbactam, daptomycin, gentamicin, linezolid, quinupristin/dalfopristin, rifampin, and vancomycin by Etest and time-kill methods. A number of combinations demonstrated either synergistic or additive effects against hGISA SA 118 and GISA SA 179. Agreement between the Etest and time-kill methods for detecting antimicrobial synergy ranged from 66.6% to 71.4%. The Etest method appears promising, and further investigations are warranted. (c) 2006 Elsevier Inc. All rights reserved.
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