Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 47, Issue 1, Pages 14-23Publisher
WILEY
DOI: 10.1111/j.1574-695X.2006.00057.x
Keywords
Malassezia; atopic dermatitis; dendritic cell; keratinocyte; inflammatory response
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Malassezia spp. are members of the normal cutaneous flora, but are also associated with several cutaneous diseases. Recent studies of the interaction of Malassezia spp. with melanocytes, fibroblasts, keratinocytes and dendritic cells have highlighted their potential to modulate the immune response directed against them. In normal skin they may downregulate the inflammatory response, allowing them to live as commensals. In contrast, in atopic/eczema dermatitis syndrome and psoriasis, they may elicit an inflammatory response that contributes to the maintenance of lesions. Future research may define ways to influence this inflammatory cycle and hence to control or prevent exacerbations of these diseases.
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