Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 6, Issue 6, Pages 711-717Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955706777435698
Keywords
protein kinases; tyrosine kinases; serine/threonine kinases; non-ATP competitive inhibitor; allosteric binding; library design
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The majority of marketed and late stage development kinase inhibitors are reported to be ATP-competitive. As a result, many promising drug candidates display non-specific activity that results in undesired physiological effects. There is growing interest towards non-ATP competitive kinase inhibitors, as they are expected to yield highly specific and efficacious molecules devoid of non-mechanistic toxicity. Recent developments in this area are summarized in our review.
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