Journal
JOURNAL OF INFECTION
Volume 52, Issue 6, Pages 405-414Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2005.08.016
Keywords
Aspergillus; osteomyelitis; anti-fungal pharmacology
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Objectives: To produce recommendations for the management of Aspergillus osteomyelitis and joint infections. Methods: Published literature was surveyed to identify both case reports of Aspergillus osteomyelitis and joint infections and anti-fungal pharmacology of anti-fungal agents. Included in the pharmacological review was an assessment of new and investigational anti-fungals to consider their potential role in the management of this infection. Results: Successful treatments, identified from the cases reviewed, were based on combination anti-fungal therapy with one agent having good bone penetration and one having reliable anti-Aspergillus activity. Conclusions: For the management of serious Aspergillus osteomyleitis/joint infections amphotericin B in combination with flucytosine is recommended. A number. of second Line treatment combinations are identified. Monotherapy is appropriate with an azole in clinically stable patients. (C) 2006 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
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