Journal
IMMUNOLOGICAL REVIEWS
Volume 211, Issue -, Pages 154-163Publisher
WILEY
DOI: 10.1111/j.0105-2896.2006.00401.x
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Funding
- NATIONAL CANCER INSTITUTE [R01CA038355, R37CA038355] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI045809, R01AI046710] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG020186, P01AG001743] Funding Source: NIH RePORTER
- NCI NIH HHS [CA038355] Funding Source: Medline
- NIAID NIH HHS [AI046710, AI045809] Funding Source: Medline
- NIA NIH HHS [AG001743, AG020186] Funding Source: Medline
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The pool of memory T cells is regulated by homeostatic mechanisms to persist for prolonged periods at a relatively steady overall size. Recent work has shown that two members of the common gamma chain (gamma c) family of cytokines, interleukin-7 (IL-7) and IL-15, govern homeostasis of memory T cells. These two cytokines work in conjunction to support memory T-cell survival and intermittent background proliferation. Normal animals contain significant numbers of spontaneously arising memory-phenotype (MP) cells, though whether these cells are representative of true antigen-specific memory T cells is unclear. Nevertheless, it appears that the two types of memory cells do not display identical homeostatic requirements. For antigen-specific memory CD8(+) T cells, IL-7 is primarily important for survival while IL-15 is crucial for their background proliferation. For memory CD4(+) T cells, IL-7 has an important role, whereas the influence of IL-15 is still unclear.
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