Journal
RESPIRATION
Volume 73, Issue 2, Pages 248-249Publisher
KARGER
DOI: 10.1159/000088010
Keywords
amiodarone; adult respiratory distress syndrome; optic neuropathy; steroids
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Acute lung toxicity is a rare but classical complication of amiodarone therapy. We report the case of a patient who developed an optic neuropathy after 15 years of amiodarone administration, and who was treated for 2 weeks with steroids. Following withdrawal of steroids, the patient rapidly developed an acute respiratory distress syndrome. Postmortem lung histologic examination was consistent with amiodarone-induced pneumonitis. Since this complication is thought to be of immunological origin, we speculate that the sudden withdrawal of steroids was implicated in the development of the acute lung injury. Copyright (C) 2006 S. Karger AG, Basel.
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