Journal
JOURNAL OF INTERNAL MEDICINE
Volume 259, Issue 1, Pages 70-80Publisher
WILEY
DOI: 10.1111/j.1365-2796.2005.01590.x
Keywords
torsades de pointes; long QT syndrome; proarrhythmias; drugs
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The steadily increasing list of drugs associated with prolongation of the QT interval and torsades de pointes (TdP) constitute a medical problem of major concern. Hence, there is a need at an early stage to identify drug candidates with an inherent capacity to induce repolarization-related proarrhythmias, avoiding exposure of large populations to potentially harmful drugs. Furthermore, the availability of clinically relevant and predictive animal models should reduce the risk that effective and potentially life-saving drugs never reach the market. This review will discuss the pros and cons of some in vivo and in vitro animal models for assessing proarrhythmia liability.
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