Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 6, Issue 3, Pages 245-270Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802606776173456
Keywords
SARMs; AR; modulation; tissue selectivity; testosterone; clihydrotestosterone; estradiol; hypogonadism
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Modulation of the androgen receptor has the potential to be an effective treatment for hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis, benign prostatic hyperplasia, and sexual dysfunction. Side effects associated with classical anabolic steroid treatments have driven the quest for drugs that demonstrate improved therapeutic profiles. Novel, non-steroidal compounds that show tissue selective activity and improved pharmacokinetic properties have been developed. This review provides an overview of current advances in the development of selective androgen receptor modulators (SARMs).
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