Journal
BIOLOGY OF THE NEONATE
Volume 89, Issue 4, Pages 330-335Publisher
KARGER
DOI: 10.1159/000092870
Keywords
ductus arteriosus patency, regulation; ductus arteriosus, anatomic closure-histologic changes; ductus arteriosus, hemodynamic and pulmonary alterations
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A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed. Copyright (c) 2006 S. Karger AG, Basel.
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