Journal
PAEDIATRIC RESPIRATORY REVIEWS
Volume 7, Issue -, Pages S73-S75Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.prrv.2006.04.169
Keywords
particles; airway wall; surfactant; macrophages; dendritic cells
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Inhaled particles may cause increased pulmonary and cardiovascular morbidity and mortality. The wall structures of airways and alveoli act as a series of structural and functional barriers against inhaled particles. Deposited particles are displaced and come into close association with epithelial cells, macrophages and dendritic cells. The cellular interplay after particle deposition in a triple cell co-culture model of the human airway wall was investigated by laser scanning microscopy. Furthermore, the cellular response was determined by measurement of TNF-alpha. Dendritic cells gained access to the apical side of the epithelium where they sampled particles and interacted with macrophages. (C) 2006 Elsevier Ltd. All rights reserved.
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