Journal
NEUROPSYCHOBIOLOGY
Volume 53, Issue 3, Pages 153-156Publisher
KARGER
DOI: 10.1159/000093341
Keywords
brain-derived neurotrophic factor (BDNF); polymorphism, BDNF; obesity
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Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 +/- 3.77 vs. 24.72 +/- 4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship. Copyright Q 2006 S. Karger AG, Basel.
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