Journal
CHEMMEDCHEM
Volume 1, Issue 1, Pages 54-57Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200500037
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Funding
- NIGMS NIH HHS [P01 GM 056550-08/C21] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM056550] Funding Source: NIH RePORTER
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High affinity dual antagonist: The envelope glycoprotein gp120 of HIV-1 mediates the first steps of viral entry into the host cell. An azidoproline-based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell-surface receptor and 17b (an antibody surrogate of the CCR5 co-receptor). It represents a potentially effective approach in preventing HIV infection.
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