Journal
PHARMACOLOGY & THERAPEUTICS
Volume 109, Issue 1-2, Pages 173-197Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2005.06.015
Keywords
calcitonin receptor; CL receptor; family B GPCR; GPCR; RAMP; VPAC1 receptor
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Funding
- Biotechnology and Biological Sciences Research Council [C20091, C20090] Funding Source: Medline
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Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs) has transformed over the last decade. Once considered as largely independent functional units (aside from their interaction with the G-protein itself), it is now clear that a single GPCR is but part of a multifaceted signaling complex, each component providing an additional layer of sophistication. Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function. They act as pharmacological switches, modifying GPCR pharmacology for a particular subset of receptors. However, there is accumulating evidence that these ubiquitous proteins have a broader role, regulating signaling and receptor trafficking. This article aims to provide the reader with a comprehensive appraisal of RAMP literature and perhaps some insight into the impact that their discovery has had on those who study GPCRs. (c) 2005 Elsevier Inc. All rights reserved.
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