Journal
NEUROPSYCHOBIOLOGY
Volume 53, Issue 3, Pages 127-132Publisher
KARGER
DOI: 10.1159/000092542
Keywords
suicide; nitric oxide; risk-rescue rating scale; depression; bipolar disorder; schizophrenia
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Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NOx) and suicide attempt. Method: Plasma NOx levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma. NOx levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NOx levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients. Copyright (c) 2006 S. Karger AG, Basel.
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