Journal
CHEMMEDCHEM
Volume 1, Issue 1, Pages 41-44Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200500056
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Funding
- NATIONAL CANCER INSTITUTE [R01CA100202] Funding Source: NIH RePORTER
- NCI NIH HHS [1R01 CA100202-01] Funding Source: Medline
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De novo designed and synthesized methylthiopyrazole epothilone B boasts a stunning biological profile against tumor cells, with activity at sub-nano-molar (IC50=0.06 nM) concentrations.
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