Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 12, Issue 3, Pages 325-328Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/135248505ms1277oa
Keywords
biomarker; MSSS; multiple sclerosis
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Funding
- Multiple Sclerosis Society [835] Funding Source: Medline
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This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SMI35, R = 0.44, P = 0.016). The degree of neurofilament phosphorylation (ratio NfH-SMI34 to NfH-SMI35) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P = 0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS.
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