Journal
TOXICOLOGIC PATHOLOGY
Volume 34, Issue 5, Pages 466-503Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01926230600867750
Keywords
red pulp; white pulp; lymphoma; lymphoid hyperplasia; mononuclear cell leukemia; LGL leukemia
Categories
Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [N01ES095435] Funding Source: NIH RePORTER
- NIEHS NIH HHS [N01 ES 35513, N01 ES 95435] Funding Source: Medline
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The spleen contains hematopoietic and lymphoid elements, is a primary site of extramedullary hematopoiesis, and removes degenerate and aged red blood cells as well as particulate materials and circulating bacteria from the blood supply. Lesions of this important component of the immune system may center on the red pulp, the white pulp or involve both compartments The spleen is the site of direct and indirect toxicity, a target for some carcinogens, and also a site for metastatic neoplasia. Many systemic or generalized diseases have splenic involvement. This paper documents spontaneous background and treatment-induced lesions seen in rodent toxicity and carcinogenicity studies.
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