Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 31, Issue 9, Pages 526-532Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2006.07.007
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Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila, provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process.
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