Journal
CANCER GENE THERAPY
Volume 13, Issue 9, Pages 830-844Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cgt.7700928
Keywords
review; vector targeting; adenovirus
Categories
Funding
- NCI NIH HHS [R01 CA111569-01A1, R01 CA083821, R01 CA111569, R01 CA094084] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA094084, R01CA083821, R01CA111569] Funding Source: NIH RePORTER
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Cancer gene therapy approaches will derive considerable benefit from adenovirus (Ad) vectors capable of self-directed localization to neoplastic disease or immunomodulatory targets in vivo. The ablation of native Ad tropism coupled with active targeting modalities has demonstrated that innate gene delivery efficiency may be retained while circumventing Ad dependence on its primary cellular receptor, the coxsackie and Ad receptor. Herein, we describe advances in Ad targeting that are predicated on a fundamental understanding of vector/cell interplay. Further, we propose strategies by which existing paradigms, such as nanotechnology, may be combined with Ad vectors to form advanced delivery vehicles with multiple functions.
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