Journal
MOLECULAR CARCINOGENESIS
Volume 45, Issue 9, Pages 701-709Publisher
WILEY
DOI: 10.1002/mc.20240
Keywords
animal models; signal pathway; gene regulation; multidrug resistance
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Funding
- NCI NIH HHS [CA79085, CA72404] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA072404, R01CA079085] Funding Source: NIH RePORTER
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Hepatocellular carcinoma (HCC) has traditionally been an attractive system for cancer research because many animal HCC models are available. It is well known that liver tumors in animals can be induced by many different protocols, such as chronic hepatitis viral infections, carcinogens, toxins, steroid hormones, and dietary intervention. Although these different inducers have different cellular targets and modes of cytotoxic effects, their common denominator is the formation of reactive oxygen species (ROS). In this review, we present compelling evidence to support the hypothesis that ROS play important roles in hepatocarcinogenesis and the associated upregulation of drug resistance gene expression. (c) 2006 Wiley-Liss, Inc.
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