Journal
CURRENT OPINION IN RHEUMATOLOGY
Volume 18, Issue 5, Pages 451-455Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.bor.0000240353.99808.5f
Keywords
B cell receptor signaling; B cell signaling abnormalities; human SLE
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Purpose of review The purpose of this review is to inform the scientific community of the most recent findings surrounding B cell receptor signaling function in human systemic lupus erythematosus and how altered B cell signaling may explain the characteristic hyperactivity of B cells in active disease and contribute to its pathogenesis. Recent findings B cell receptor signaling is abnormal in patients with active systemic lupus erythematosus as demonstrated by increased calcium flux and global B cell hyperactivity. Altered signaling has been explained by a variety of factors such as defective Fc gamma RIIB signaling, decreased expression of the protein tyrosine kinase Lyn, and increased serum levels of B lymphocyte stimulator. Summary The studies reviewed suggest that B cells from systemic lupus erythematosus patients display molecular signaling defects that most likely contribute to pathogenesis of the disease and explain the characteristic hyperactivity of B cells in active disease.
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