Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 27, Issue 9, Pages 492-497Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2006.07.002
Keywords
-
Categories
Ask authors/readers for more resources
Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in the regulation of smooth muscle contraction, including that of the urinary bladder. Recent experimental evidence indicates that this role could be deregulated and exacerbated in local and systemic pathological conditions that affect the bladder. In vitro studies with prototypical ROCK inhibitors such as Y27632 and in vivo data from animal models indicate that such drugs have potential as future treatments for bladder dysfunction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available