Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 27, Issue 6, Pages 338-344Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2006.04.007
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DNA-damaging agents have a central role in nonsurgical cancer treatment. The balance between DNA damage and repair determines the final therapeutic consequences. An elevated DNA-repair capacity in tumor cells leads to drug or radiation resistance and severely limits the efficacy of these agents. Interference with DNA repair has emerged as an important approach in combination therapy against cancer. Anticancer targets in DNA-repair systems have emerged, against which several small-molecule compounds are currently undergoing clinical trials.
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