Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 16, Issue 3, Pages 289-292Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2006.04.014
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- Telethon [B.38] Funding Source: Medline
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Sex determination in mammals is based on a genetic cascade that controls the fate of the gonads. Gonads will then direct the establishment of phenotypic sex through the production of hormones. Different types of sex reversal are expected to occur if mutations disrupt one of the three steps of gonadal differentiation: formation of the gonadal primordia, sex determination, and testis or ovary development.
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