Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 18, Issue 3, Pages 363-370Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2006.03.009
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Funding
- DIVISION OF CLINICAL SCIENCES - NCI [Z01SC006670] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [Z01BC010763] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 BC010763-01, Z99 CA999999] Funding Source: Medline
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The differentiation state of CD8(+) T cells has emerged as a crucial determinant of their ability to respond to tumor and infection. Signals from T-cell receptors, co-stimulatory molecules and cytokine receptors direct the differentiation process. These signals 'program' sustained and heritable gene expression patterns that govern progressive differentiation and lineage commitment. The epigenetic mechanisms by which T cells are programmed are just beginning to be elucidated. Understanding the mechanisms that control CD8(+) T-cell differentiation is important in the development of novel immunotherapy strategies.
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