Journal
QSAR & COMBINATORIAL SCIENCE
Volume 25, Issue 5-6, Pages 432-438Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/qsar.200540201
Keywords
Multicomponent Reactions; domino reactions; 1,3-dicarbonyls; Michael addition; heterocycles
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The aim of this mini-review is to present an overview of the high synthetic potential of Multicomponent Reactions (MCRs) involving the specific reactivity of easily accessible 1,3-dicarbonyl derivatives. The present contribution only focuses on sequences in which the first step consists of a Michael addition. Recent developments of these new useful methodologies valuable for the selective construction of highly functionalized heterocycles of high synthetic value are surveyed.
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