Journal
TRENDS IN MICROBIOLOGY
Volume 14, Issue 6, Pages 271-276Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2006.04.003
Keywords
-
Categories
Funding
- Medical Research Council [G0401038] Funding Source: Medline
- MRC [G0401038] Funding Source: UKRI
Ask authors/readers for more resources
When stressed, bacteria can enter various non-dividing states, which are medically important. For example, dormancy is used by Mycobacterium tuberculosis to evade host responses. A major breakthrough has been the discovery of resuscitation-promoting factor (Rpf) from Micrococcus luteus, which is an extremely potent anti-dormancy factor. Mycobacteria have multiple proteins that contain this domain. Surprisingly, the highly conserved resuscitation-promoting factor domain has strong structural similarities to lysozyme and soluble lytic transglycosylases, and it has been demonstrated that resuscitation-promoting factors cleave peptidoglycan. This suggests that the activation of dormant cells requires peptidoglycan hydrolysis, which either alters the mechanical properties of the cell wall to facilitate cell division or releases lysis products that function as antidormancy signals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available