Journal
TRENDS IN GENETICS
Volume 22, Issue 6, Pages 320-329Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2006.03.008
Keywords
-
Categories
Ask authors/readers for more resources
Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available