Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 46, Issue 1, Pages 65-77Publisher
HUMANA PRESS INC
DOI: 10.1385/CBB:46:1:65
Keywords
Drosophila; epithelial cells; glial cells; septate junctions; myelinated axons; axo-glial junctions; NCP family; neurexin; contactin; neuroglian; neurofascin
Funding
- NATIONAL CANCER INSTITUTE [K01CA078437] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063074] Funding Source: NIH RePORTER
- NCI NIH HHS [CA78437] Funding Source: Medline
- NIGMS NIH HHS [GM63074] Funding Source: Medline
Ask authors/readers for more resources
In most cell types, distinct forms of intercellular junctions have been visualized at the ultrastructural level. Among these, the septate junctions are thought to seal the neighboring cells and thus to function as the paracellular barriers. The most extensively studied form of septate junctions, referred to as the pleated septate junctions, is ultrastructurally distinct with an electron-dense ladder-like arrangement of transverse septa present in invertebrates as well as vertebrates. In invertebrates, such as the fruit fly Drosophila melanogaster, septate junctions are present in all ectodermally derived epithelia, imaginal discs, and the nervous system. In vertebrates, septate junctions are present in the myelinated nerves at the paranodal interface between the myelin loops and the axonal membrane. In this review, we present an evolutionary perspective of septate junctions, especially their initial identification across phyla, and discuss many common features of their morphology, molecular organization, and functional similarities in invertebrates and vertebrates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available