Journal
EUROPEAN PSYCHIATRY
Volume 21, Issue 1, Pages 70-73Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2005.11.001
Keywords
neurophysiology; schizophrenia; biological marker; endophenotype; P300; COMT gene
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Funding
- National Institute for Health Research [PDA/02/06/016] Funding Source: researchfish
- Wellcome Trust Funding Source: Medline
- Department of Health [PDA/02/06/016] Funding Source: Medline
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P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Va1158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any Such association, if present, must be very subtle. (c) 2006 Elsevier SAS. All rights reserved.
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