Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 22, Issue 4, Pages 306-311Publisher
KARGER
DOI: 10.1159/000095303
Keywords
amnestic mild cognitive impairment; Alzheimer's disease; executive function; fluency
Categories
Funding
- NATIONAL INSTITUTE ON AGING [P50AG016570, P50AG005142, R01AG022538, P30AG010129] Funding Source: NIH RePORTER
- NIA NIH HHS [L30 AG024692, AG10129, P50 AG005142, P30 AG010129, R01 AG022538-02, P50-AG05142, AG16570, P50 AG016570, R01 AG022538] Funding Source: Medline
Ask authors/readers for more resources
Objective: To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form of mild cognitive impairment (MCI). Methods: From a larger sample of patients clinically diagnosed as meeting the criteria of Petersen et al. for amnestic MCI, we selected 22 subjects who had Clinical Dementia Rating scores of zero on all domains besides memory and orientation. These MCI subjects with presumably isolated memory impairments were compared to 35 age-matched normal controls and 33 very mild Alzheimer's disease ( AD) patients on a battery of neuropsychological tests. Result: In addition to the expected deficits in episodic memory, the amnestic MCI group performed less well than the controls but better than the AD group on design fluency, category fluency, a set shifting task and the Stroop interference condition. Over half the amnestic MCI group ( vs. none of the normal controls) scored at least 1 standard deviation below control means on 4 or more of the nonmemory cognitive tasks. Conclusions: Isolated memory impairment may be fairly uncommon in clinically diagnosed amnestic MCI patients, even when the criteria for amnestic MCI are fairly narrow. Additional cognitive impairments are likely to include fluency and executive functioning. These more diffuse deficits argue for comprehensive cognitive assessments, even when the patient and family are reporting only memory decline, and are consistent with the increase in attention paid to the heterogeneity of MCI. Copyright (C) 2006 S. Karger AG, Basel.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available