Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 30, Issue 10, Pages 954-965Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.dci.2005.12.008
Keywords
mannan-binding lectin; porcine/pigs; collectin; Actinobacillus pleuropneumoniae; Haemophilus parasuis; Actinobacillus suis; plasma proteins; innate immunity
Categories
Ask authors/readers for more resources
Various collagenous lectins involved in innate immunity bind to surface oligosaccharides of bacteria and other microorganisms. We have been characterizing porcine plasma lectins that bind in a carbohydrate-dependent manner to surfaces of important bacterial pig pathogens including Actinobacillus suis (AS), A. pleuropneumoniae (APP), and Haemophilus parasuis (HP). A plasma protein with 32 kDa subunits (pI 5.4 and 5.75) bound most isolates of HP, AS, and some APP. Partial amino acid sequences of this protein were similar to mammalian mannan-binding lectins (MBLs). The corresponding MBL-A cDNA sequences obtained by RT-PCR on liver tissue from pigs and cattle were homologous to the MBL1 gene of mice, rats and the MBL1P1 pseudogene of humans and chimpanzees. While human MBL-C, the product of the MBL2 gene, is known to bind various microorganisms, our studies in pigs provide the first direct evidence that MBL-A has bacteria-binding properties, and suggest it may have antibacterial functions in pigs. (c) 2006 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available