Journal
JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
Volume 83, Issue 1, Pages 5-17Publisher
SPRINGER
DOI: 10.1007/s11524-005-9003-8
Keywords
resistance; HIV infection; susceptibility; progression
Funding
- NIAID NIH HHS [P30 AI027742, AI27742, T32 AI007382, AI057127, P01 AI057127, 5T32 AI007382] Funding Source: Medline
- NIDA NIH HHS [DA15303, R01 DA015303] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI027742, P01AI057127, T32AI007382] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA015303] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The biological correlates of an effective immune response that could contain or prevent HIV infection remain elusive despite substantial scientific accomplishments in understanding the interactions among the virus, the individual and the community. The observation that some individuals appear to possess resistance to HIV infection or its consequences has generated a host of epidemiologic investigations to identify biological or behavioral characteristics of these individuals. These data might bold the keys to developing appropriate strategies for mimicking the effective responses of those who appear immune. In this paper we review genetic mechanisms including the role of chemokines and their receptors, cytokines, host genetic immune response to HIV infection, local immune response correlating with behavioral variables co-infection and immune based mechanisms that have been elucidated so far. We offer suggestions for how to use these observations as platforms for future research to further understand natural resistance to HIV infection through cohort studies, population genotype sampling, mathematical modeling of virus-host interactions and behavioral analyses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available