Journal
HIPPOCAMPUS
Volume 16, Issue 7, Pages 604-616Publisher
WILEY
DOI: 10.1002/hipo.20190
Keywords
hippocampus; neuroimaging; lesion; subsequent memory; Korsakoff's syndrome
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059940, R01MH057681] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS026985] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG012995] Funding Source: NIH RePORTER
- NIA NIH HHS [AG12995] Funding Source: Medline
- NIMH NIH HHS [MH59940, MH57681, R01 MH057681] Funding Source: Medline
- NINDS NIH HHS [NS 26985, P50 NS026985] Funding Source: Medline
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Behavioral studies with amnesic patients and imaging studies with healthy adults have suggested that medial temporal lobe (MTL) structures known to be essential for long-term declarative memory (LTM) may also be involved in the maintenance of information in working memory (WM). To examine whether MTL structures are involved in WM maintenance for faces, and the nature of that involvement, WM and LTM for faces were examined in normal participants via functional magnetic resonance imaging (fMRI) and in amnesic patients behaviorally. In Experiment 1, participants were scanned while performing a WM task in which they determined if two novel faces, presented 7 s apart, were the same or different. Later, participants' LTM for the faces they saw during the WM task was measured in an unexpected recognition test. During WM maintenance, the hippocampus was activated bilaterally, and there was greater activation during maintenance for faces that were later remembered than faces later forgotten. A conjunction analysis revealed overlap in hippocampal activations across WM maintenance and LTM contrasts, which suggested that the same regions were recruited for WM maintenance and LTM encoding. In Experiment 2, amnesic and control participants were tested on similar WM and LTM tasks. Amnesic patients, as a group, had intact performance with a 1-s maintenance period, but were impaired after a 7-s WM maintenance period and on the LTM task. Thus, parallel neuroimaging and lesion designs suggest that the same hippocampal processes support WM maintenance, for intervals as short as 7 s, and LTM for faces. (c) 2006 Wiley-Liss, Inc.
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