Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 21, Issue 5-6, Pages 335-352Publisher
KARGER
DOI: 10.1159/000091789
Keywords
dementia, vascular disease; dementia, hematologic risk factors; vascular dementia; blood-brain barrier; homocysteine; cholesterol; fatty acids; antioxidants; C-reactive protein
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Funding
- NIA NIH HHS [R01 AG11380, R01 AG19825, P01 AG05146] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P50AG005146, R01AG011380, R01AG019825] Funding Source: NIH RePORTER
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Multiple studies have implicated vascular-related conditions as risk factors for dementia. Clarification of these factors in dementia is important because most are modifiable, and may serve as the basis for preventive strategies. Several hematologic factors are associated with vascular diseases, but their relation to dementia is unclear. This review examines biological and epidemiological evidence concerning the role of these hematologic factors in dementia, and dementia subtypes. Reviewed factors include homocysteine, cholesterol, fatty acids, antioxidants, and C-reactive protein. The vast majority of studies reviewed are cross-sectional. Longitudinal studies with serial hematologic measures are needed to clarify the relationship between these factors and dementia over the lifespan. A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated. Copyright (C) 2006 S. Karger AG, Basel.
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