Journal
CHRONOBIOLOGY INTERNATIONAL
Volume 23, Issue 1-2, Pages 39-51Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07420520500482074
Keywords
melatonin; suprachiasmatic nucleus; circadian system; pineal gland; peripheral oscillators
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In mammals, the complex interaction of neural, hormonal, and behavioral outputs from the suprachiasmatic nucleus (SCN) drives circadian expression of events, either directly or through coordination of the timing of peripheral oscillators. Melatonin, one of the endocrine output signals of the clock, provides the organism with circadian information and can be considered as an endogenous synchronizer, able to stabilize and reinforce circadian rhythms and to maintain their mutual phase-relationship at the different levels of the circadian network. Moreover, exogenous melatonin, through an action on the circadian clock, affects all levels of the circadian network. The molecular mechanisms underlying this chronobiotic effect have also been investigated in rats. REV-ERB alpha seems to be the initial molecular target.
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