Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 31, Issue 1, Pages 41-51Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2005.11.008
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Twenty-two years after their discovery as ribozymes, the self-splicing group I introns are finally disclosing their architecture at the atomic level. The crystal structures of three group I introns solved at moderately high resolution (3.1-3.8 angstrom) reveal a remarkably conserved catalytic core bound to the metal ions required for activity. The structure of the core is stabilized by an intron-specific set of long-range interactions that involves peripheral elements. Group I intron structures thus provide much awaited and extremely valuable snapshots of how these ribozymes coordinate substrate binding and catalysis.
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