Journal
TRENDS IN IMMUNOLOGY
Volume 27, Issue 6, Pages 282-290Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2006.04.004
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Myeloid cells are usually viewed as targets rather than producers of interferon (IFN)-gamma. However, since 1993 several studies have suggested that macrophages and dendritic cells can also secrete IFN-gamma in response to various stimuli, which led to the idea of autocrine myeloid-cell activation in innate immunity. Here, we review this concept in the light of recent findings that illustrate the necessity of specific cell markers, cell purity, sensitive single-cell cytokine detection methods, and of further insights into the developmental origin of myeloid and lymphoid cell lineages. We also discuss the possible function of intracellular IFN-gamma in macrophages and the evidence for a protective role of myeloid IFN-gamma in vivo.
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