Journal
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY
Volume 100, Issue 4, Pages 327-336Publisher
MANEY PUBLISHING
DOI: 10.1179/136485906X105589
Keywords
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Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR018727, G12RR003061] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U54AI065359] Funding Source: NIH RePORTER
- NCRR NIH HHS [P20 RR 018727, G12 RR003061] Funding Source: Medline
- NIAID NIH HHS [U54 AI065359] Funding Source: Medline
- PHS HHS [U50/CCU 912395-07, U50/CCU 912395-06] Funding Source: Medline
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In 2000, a major dengue epidemic, caused by the type-1 virus (DENV-1), began in the Pacific and Asia, with cases still being reported in 2006. The phylogenetic analysis of full-length sequences of the envelope-protein gene of DENV-1 isolates recovered during outbreaks in Hawaii and Tahiti in 2001-2002 indicated that most Hawaiian isolates were Tahitian in origin. All the Hawaiian and Tahitian isolates were identified as the Pacific subtype (i.e. subtype IV) of DENV-1. A Hawaiian isolate, collected from a resident who had travelled to Samoa, differed significantly at the nucleotide level, however, from all the other Hawaiian strains, clustering, in the phylogenetic analysis, with a virus previously isolated from another visitor to Samoa. These results not only indicate that two distinct strains of DENV-1 were introduced into Hawaii in 2001 but also illustrate the ease with which dengue can be carried across distances of many thousands of miles.
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