Journal
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
Volume 14, Issue 1, Pages 79-84Publisher
WESTMINSTER PUBL INC
DOI: 10.1177/106689690601400116
Keywords
breast carcinoma; papillary carcinoma; thyroid; BRAF; cytology
Ask authors/readers for more resources
The breast tumor resembling the tall cell variant of papillary thyroid carcinoma is a very unusual mammary carcinoma whose histologic and predominant nuclear features mimic a papillary thyroid carcinoma. We report the case of a 64-year-old woman who presented with a palpable nodule in the right breast. Fine needle aspiration disclosed abundant cellularity with isolated cells, sheets, and papillary formations of epithelial cells with nuclear grooves. Histologically, the neoplastic cells were arranged in a solid to papillary architecture, with follicular- like and cribriform areas. The cells were columnar to cuboidal with eosinophilic cytoplasm, clear chromatin, nuclear grooves, and occasional nuclear pseudoinclusions. Tumor cells were positive for cytokeratins, alpha and beta-estrogen receptors, progesterone receptor, androgen receptor, CEA, and bcl-2. We searched for BRAF mutations with negative results. Recognizing the cytologic and histologic characteristics Of these Peculiar mammary tumors that mimic thyroid carcinomas can avoid unnecessary clinical investigations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available