Journal
TRENDS IN NEUROSCIENCES
Volume 29, Issue 1, Pages 8-20Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2005.11.002
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH070860] Funding Source: NIH RePORTER
- NIMH NIH HHS [R01 MH070860-01A1, R01 MH070860] Funding Source: Medline
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Central neurons develop and maintain molecularly distinct synaptic specializations for excitatory and inhibitory transmitters, often only microns apart on their dendritic arbor. Progress towards understanding the molecular basis of synaptogenesis has come from several recent studies using a coculture system of non-neuronal cells expressing molecules that generate presynaptic or postsynaptic 'hemi-synapses' on contacting neurons. Together with molecular properties of these protein families, such studies have yielded interesting clues to how glutamatergic and GABAergic synapses are assembled. Other clues come from heterochronic cultures, manipulations of activity in subsets of neurons in a network, and of course many in vivo studies. Taking into account these data, we consider here how basic parameters of synapses competence, placement, composition, size and longevity - might be determined.
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